ARUP's Laboratory Test Directory
| 0080436: Metanephrines, Urine |
| Test Mnemonic: META UF | |
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#ExistMethodology>
Methodology: Gas Chromatography/Mass Spectrometry
*ExistMethodology> #ExistPerformed> Performed: Sun-Sat *ExistPerformed> #ExistReported> Reported: 1-3 days *ExistReported> |
| Specimen Required: | |
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#ExistCollect>
Collect: 24-hour or random urine. Refrigerate 24-hour sample during collection.
*ExistCollect> #ExistTransport> Transport: 5 mL aliquot from a well-mixed 24-hour or random collection at 2-8°C. (Min: 1.5 mL) Submit specimen in an ARUP Standard Transport Tube. Record total volume and collection time interval on transport tube and test request form. *ExistTransport> #ExistPedCollectTransport> Pediatric Collection/Transport: 1.5 mL aliquot from a well-mixed 24-hour collection at 2-8°C. Record total volume and collection time interval on transport tube and test request form. *ExistPedCollectTransport> #ExistRemarks> Remarks: Adequate refrigeration is the most important aspect of specimen preservation. Stability is enhanced at pH 2-3. A pH lower than 2 may cause assay interference. *ExistRemarks> #ExistStability> Stability: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 month *ExistStability> |
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#ExistRefRangeTable>
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| Note: | |
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Secreting neuroendocrine tumors typically are associated with metanephrine or normetanephrine concentrations several times higher than the upper reference intervals. Other reasons for elevated concentrations include intense physical activity, life-threatening illness, and drug interferences. Essential hypertension is often associated with slight elevations (metanephrine less than 700 µg/day and normetanephrine less than 900 µg/day). Other reasons for slight and moderate elevations include emotional and physical stress and improper specimen collection. Medications which may physiologically interfere with metanephrines include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), methyldopa (Aldomet), MAO inhibitors, nose drops, propafenone (Rythmol), tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predictable. |
| CPT Code(s): | |
| 83835 |