Reference Interval:
| | | Components
| Reference Interval (18 years and older)
| | Metanephrine
| 152-1775 nmol/d
| | Normetanephrine
| 273-3548 nmol/d
|
| The metanephrines-to-creatinine ratios will be reported when the patient is under 18 years, or the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours.
| | Test Number
| Components
| Reference Interval
| | | Metanephrine | | | | Age
| Reference Interval
| 0-3 months
4-6 months
7-11 months
1 year
2-5 years
6-17 years
18 years and older
| 0-402 µmol/mol crt
0-373 µmol/mol crt
0-373 µmol/mol crt
0-304 µmol/mol crt
0-287 µmol/mol crt
0-184 µmol/mol crt
0-172 µmol/mol crt
|
| | | Normetanephrine | | | | Age
| Reference Interval
| 0-3 months
4-6 months
7-11 months
1 year
2-5 years
6-17 years
18 years and older
| 0-2098 µmol/mol crt
0-1357 µmol/mol crt
0-679 µmol/mol crt
0-802 µmol/mol crt
0-376 µmol/mol crt
0-278 µmol/mol crt
0-247 µmol/mol crt
|
| | | Creatinine (24-hour)
| | Male
| Female
| 3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 500-2300 mg/d
18-50 years: 1000-2500 mg/d
51-80 years: 800-2100 mg/d
81 years and older: 600-2000 mg/d
| 3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 400-1600 mg/d
18-50 years: 700-1600 mg/d
51-80 years: 500-1400 mg/d
81 years and older: 400-1300 mg/d
|
|
|
| Interpretive Data: |
Ratios to creatinine may be useful for evaluation of patients younger than 18 years of age, when the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours.
Moles per day (nmol or µmol) calculations are not reported when the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours.
Smaller increases in normetanephrine and/or Metanephrine concentrations (less than two times the upper reference limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or both metanephrines (3 or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor.
|
| Note: |
Secreting neuroendocrine tumors typically are associated with metanephrine or normetanephrine concentrations several times higher than the upper reference intervals. Other reasons for elevated concentrations include intense physical activity, life-threatening illness, and drug interferences. Essential hypertension is often associated with slight elevations (metanephrine less than 3500 nmol/day and normetanephrine less than 4900 nmol/day). Other reasons for slight and moderate elevations include emotional and physical stress and improper specimen collection.
|
| CPT Code(s): |
83835
|
|