ARUP's Laboratory Test Directory

0080436: Metanephrines, Urine

Test Mnemonic: META UF
Methodology: Gas Chromatography/Mass Spectrometry

Performed: Sun-Sat

Reported: 1-3 days

Specimen Required:  
Collect: 24-hour or random urine. Refrigerate 24-hour sample during collection. 

Transport: 5 mL aliquot from a well-mixed 24-hour or random collection at 2-8°C. (Min: 1.5 mL) Submit specimen in an ARUP Standard Transport Tube.  Record total volume and collection time interval on transport tube and test request form.

Pediatric Collection/Transport: 1.5 mL aliquot from a well-mixed 24-hour collection at 2-8°C.  Record total volume and collection time interval on transport tube and test request form.

Remarks: Adequate refrigeration is the most important aspect of specimen preservation. Stability is enhanced at pH 2-3. A pH lower than 2 may cause assay interference.

Stability: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 month

Reference Interval:
 
 
Components Reference Interval
Metanephrine 30-350 µg/d
Normetanephrine 50-650  µg/d

 
The metanephrines-to-creatinine ratios will be reported when the patient is under 18 years, or the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours.
Test Number Components Reference Interval
 Metanephrine 
 
 
Age Reference Interval
0-3 months
4-6 months
7-11 months
1 year
2-5 years
6-17 years
18 years and older 		0-700 µg/g crt
0-650 µg/g crt
0-650 µg/g crt
0-530 µg/g crt
0-500 µg/g crt
0-320 µg/g crt
0-300 µg/g crt
 Normetanephrine 
 
 
Age Reference Interval
0-3 months
4-6 months
7-11 months
1 year
2-5 years
6-17 years
18 years and older 		0-3400  µg/g crt
0-2200  µg/g crt
0-1100  µg/g crt
0-1300 µg/g crt
0-610 µg/g crt
0-450 µg/g crt
0-400 µg/g crt
 Creatinine (24-hour)  
 
Male Female
3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 500-2300 mg/d
18-50 years: 1000-2500 mg/d
51-80 years: 800-2100 mg/d
81 years and older: 600-2000 mg/d 		3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 400-1600 mg/d
18-50 years: 700-1600 mg/d
51-80 years: 500-1400 mg/d
81 years and older: 400-1300 mg/d

Note:
Secreting neuroendocrine tumors typically are associated with metanephrine or normetanephrine concentrations several times higher than the upper reference intervals. Other reasons for elevated concentrations include intense physical activity, life-threatening illness, and drug interferences. Essential hypertension is often associated with slight elevations (metanephrine less than 700 µg/day and normetanephrine less than 900 µg/day). Other reasons for slight and moderate elevations include emotional and physical stress and improper specimen collection.

Medications which may physiologically interfere with metanephrines include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), methyldopa (Aldomet), MAO inhibitors, nose drops, propafenone (Rythmol), tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predictable.

CPT Code(s):
83835

 

 

 
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