ARUP's Laboratory Test Directory

Serotonin, Whole Blood : 0080395

Mnemonic: SEROT-WB

Methodology: High Performance Liquid Chromatography
Performed: Sun, Wed, Fri
Reported: 1-5 days
Specimen Required: Patient Prep:  Abstain from medications for 72 hours prior to collection.

Collect:  One 3 mL lavender (EDTA) or pink (K2EDTA).  Place on ice.  Transfer whole blood into an ARUP Serotonin Transport Tube containing ascorbic acid (available through ARUP Client Services - ARUP Supply #16568).  Mix Well.  Specimen must be preserved and frozen within 2 hours of collection.

Storage/Transport Temperature:  3 mL whole blood in an ARUP Serotonin Transport Tube, frozen. (Min: 1 mL)

Remarks:  CRITICAL FROZEN. Separate samples must be submitted when multiple tests are ordered.  Serotonin, Serum (0080397) is recommended for patients that are difficult to draw.

Unacceptable Conditions:  Nonfrozen samples.

Stability (collection to initiation of testing):  After transfer to Serotonin Transport Tube: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Reference Interval:
50-200 ng/mL
Note: Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine.  In general, foods that contain serotonin do not interfere significantly.  Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue.  Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.
CPT Code(s): 84260
Cross References: 5-HT, Blood, 5-Hydroxytryptamine, Blood
 
 

 

 

 
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