ARUP's Laboratory Test Directory

Pyridinoline & Deoxypyridinoline by HPLC : 0080342

Mnemonic: PYD & DPD

Methodology: High Performance Liquid Chromatography
Performed: Wed
Reported: 6-14 days
Specimen Required: Patient Prep: First morning void.

Collect: Urine.

Specimen Preparation: Transfer 8 mL urine to ARUP Standard Transport Tubes. (Min: 4 mL)

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Random urine.

Stability (collection to initiation of testing): Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months

Reference Interval:
 
   

Age
PYR
µmol/mol creatinine
DPYR
µmol/mol creatinine

DPYR/PYR Ratio
0-11 months 353-560 µmol/mol crt 46-113 µmol/mol crt 0.13-0.20
1-3 years 108-400 µmol/mol crt 19-94 µmol/mol crt 0.18-0.24
4-9 years 117-325 µmol/mol crt 20-75 µmol/mol crt 0.19-0.25
10-14 years 81-267 µmol/mol crt 13-61 µmol/mol crt 0.17-0.27
15-19 years 38-80 µmol/mol crt 10-18 µmol/mol crt 0.20-0.26
20 years and older 20-40 µmol/mol crt 5-11 µmol/mol crt 0.23-0.29

Interpretive Data: Pyridinoline and Deoxypyridinoline excretion follows a circadian rhythm.  Reference intervals have been established on first morning void urine samples.
CPT Code(s): 82523