ARUP's Laboratory Test Directory

0080341: Oligoclonal Band Profile with MBP

Test Mnemonic: MS PRO
Methodology: Refer to individual components

Performed: Mon, Wed, Fri

Reported: 1-4 days

Specimen Required:  
Collect: One 4 mL SST and CSF.

Transport: 1 mL serum and 2 mL CSF, frozen. (Min: 0.5 mL serum and 1.5 mL CSF)  Submit serum specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.5 mL serum and 1.5 mL CSF, frozen.

Remarks: Serum specimen should be drawn within 48 hours of CSF collection.  Allow specimen to clot completely at room temperature.  Separate serum from cells ASAP.  Specimens must be assayed together for interpretation.  Avoid hemolysis.

Stability: Ambient: 8 hours; Refrigerated: 7 days; Frozen: 1 month

Reference Interval:
 
Test Number Components Reference Interval
0050350Immunoglobulin G, Serum  
 
0- 30 days: 611-1542 mg/dL             
1 month: 241-870 mg/dL                         
2 months: 198-577 mg/dL           
3 months: 169-558 mg/dL                   
4 months: 188-536 mg/dL                         
5 months: 165-781 mg/dL                         
6 months: 206-676 mg/dL                           
7-8 months: 208-868 mg/dL                        		9-11 months: 282-1026 mg/dL
1 year: 331-1164 mg/dL
2 years: 407-1009 mg/dL
3 years: 423-1090 mg/dL
4 years: 444-1187 mg/dL
5-7 years: 608-1229 mg/dL
8-9 years: 584-1509 mg/dL
10 years and older: 768-1632 mg/dL
0050670Immunoglobulin G, CSF 0-6.0 mg/dL
0050671Albumin, Serum by Nephelometry 3500-5200 mg/dL
0050200Albumin, CSF 0-35 mg/dL
 Albumin Index0.0-9.0
 CSF IgG Synthesis Rate0.0-8.0 mg/d
 IgG Index 0.28-0.66
 CSF IgG/Albumin Ratio0.09-0.25
 CSF Oligoclonal Bands Negative
0080515Myelin Basic Protein 0.07-4.10 ng/mL 
 Interpretation By report
 

Note:
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

Hemolysis is associated with falsely-elevated levels of MBP in the CSF. CSF should be free from contamination with blood, if possible. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing the sample.

CPT Code(s):
83916 Oligoclonal immune (oligoclonal bands); 83873 Myelin basic protein, cerebrospinal fluid; 82784  IgG, serum; 82784 IgG, CSF; 82040 Albumin, serum; 82042 Albumin, CSF