Maternal Serum Screen, Alpha Fetoprotein, hCG, Estriol, & Inhibin A : ARUP Lab Tests

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0080269: Maternal Serum Screen, Alpha Fetoprotein, hCG, Estriol, & Inhibin A

Patient History For Maternal Serum Testing

Test Mnemonic: AFP MS4
Methodology: Chemiluminescent Immunoassay Performed: Sun-Sat Reported: 2-3 days

Specimen Required:

Collect: One 7 mL SST or plain red. Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation.

Transport: 3 mL serum, frozen. (Min: 1 mL) Submit specimen in an ARUP Standard Transport Tube.

Remarks: The following information is required and must accompany the sample for test interpretation: patient's date of birth, current weight, due date, dating method (US, LMP), number of fetuses present, patient's race, if the patient requires insulin, if there is a known family history of neural tube defects, if the patient has had a previous pregnancy with a chromosome abnormality, if the patient is taking valproic acid or carbamazepine (Tegretol®), physician's name and phone number; and for in vitro fertilization pregnancies, the age of the egg donor. Separate serum from cells ASAP.

Unacceptable Conditions: Specimens exposed to repeated freeze/thaw cycles. Hemolyzed specimens. Heparin, EDTA, and citrate plasma.

Stability: After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 year

Reference Interval:

By report: includes AFP, hCG, Estriol, and Inhibin A.
Intervals are based upon weeks of gestation.

Note:
This test is used to screen for fetal risk of Down syndrome (trisomy 21), trisomy 18, and Open Neural Tube Defect (ONTD, spina bifida).

CPT Code(s):
82105 AFP; 84702 hCG; 82677 Estriol; 86336 Inhibin A

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