ARUP's Laboratory Test Directory

0070283: Soluble Transferrin Receptor

Test Mnemonic: STR
Methodology: Immunoturbidimetric

Performed: Sun-Sat

Reported: Within 24 hours

Specimen Required:  
Collect: One 4 mL SST, or one 3 mL green (sodium or lithium heparin). Also acceptable: lavender (EDTA) or pink (K2EDTA).

Transport: 1 mL serum or plasma, frozen. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.3 mL serum or plasma, frozen.

Unacceptable Conditions: Severely hemolyzed, icteric, contaminated, or lipemic specimens.

Stability: After separation from cells: Ambient: 4 hours; Refrigerated: 1 week; Frozen: 1 month at -20°C or 1 year at -70°C (avoid repeated freeze/thaw cycles)

Reference Interval:
Male - 18 years & older: 2.2-5.0 mg/L
Female - 18 years & older: 1.9-4.4 mg/L

Interpretive Data:
People of African descent and those residing at 5,200 feet (1,600 meters) above sea level were found to have a 6% higher normal value.  These differences were additive.  Reference intervals have not been established for pregnant females, patients under 18 years of age, and recent or frequent blood donors.

Serum soluble transferrin receptor increases in iron deficiency and is usually unaffected by chronic disease states.  In general, to increase sensitivity and specificity, the measurement of serum soluble transferrin receptor should be performed in combination with other tests of iron status, including ferritin, TIBC, and serum iron (refer to table below).

 
 Tests for Changes in: Iron Deficiency Anemia Anemia of Chronic Disease Iron Deficiency & Anemia of Chronic Disease
Ferritin Iron Stores Low High Normal or High
TIBC Iron Status High Low Normal or High
Serum Iron Iron Status Low Low Low
sTfR Iron Status High Normal High


CPT Code(s):
84238

 

 

 
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