ARUP's Laboratory Test Directory

IGF-1 (Insulin-Like Growth Factor 1) : 0070125
[ image for: IGF-1 Pubertal Ranges by Tanner Stage]
IGF-1 Pubertal Ranges by Tanner Stage
  


Mnemonic: IGF-1

Ordering Recommendation: Aids in diagnosis of growth hormone excess or deficiency disorders.
Methodology: Quantitative Chemiluminescent Immunoassay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Transport 1 mL serum. (Min: 0.5 mL) Also acceptable: Heparinized plasma.

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Tissue or urine. Grossly hemolyzed or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 year
Reference Interval:
 
Age Female Male
1-2 years
3 years
4 years
5 years
6 years
7 years
8-18 years
19-20 years
21-30 years
31-40 years
41-50 years
51-60 years
61-70 years
71-80 years 		56-144 ng/mL
26-162 ng/mL
32-179 ng/mL
39-198 ng/mL
55-238 ng/mL
55-268 ng/mL
Refer to Tanner Stages
217-475 ng/mL
87-368 ng/mL
106-368 ng/mL
118-298 ng/mL
53-287 ng/mL
75-263 ng/mL
54-205 ng/mL 		30-122 ng/mL
20-141 ng/mL
25-157 ng/mL
30-174 ng/mL
37-192 ng/mL
44-211 ng/mL
Refer to Tanner Stages
281-510 ng/mL
155-432 ng/mL
132-333 ng/mL
121-237 ng/mL
68-245 ng/mL
60-220 ng/mL
36-215 ng/mL

 
Female Tanner Stages  
I (8-12 yrs) 64-358 ng/mL
II (8-14 yrs) 89-566 ng/mL
III (9-15 yrs) 192-568 ng/mL
IV & V (11-18 yrs) 268-430 ng/mL
  
Male Tanner Stages  
I (8-15 yrs) 52-391 ng/mL
II & III (8-16 yrs) 39-648 ng/mL
IV & V (11-18 yrs) 277-434 ng/mL

Interpretive Data: IGF-1 values well above the age and gender matched reference interval indicate a possible pituitary tumor secreting growth hormone. IGF-1 values below the reference interval indicate a possible GH deficiency.
CPT Code(s): 84305
Cross References: Insulin-Like Growth Factor I (IGF-1 (Insulin-Like Growth Factor I)), Somatomedin C (IGF-1 (Insulin-Like Growth Factor I))