ARUP's Laboratory Test Directory

Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene) : 0065999

Mnemonic: HPV-HI

Methodology: Qualitative Nucleic Acid Probe
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Patient Prep: Females should avoid high concentrations of antifungal cream, contraceptive jelly, or douche at time of collection.

Collect: Cervical brush in HPV Digene Collection Kit (cervical brush and specimen transport medium, ARUP Supply #12578). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.

Specimen Preparation: Place each specimen in an individually sealed bag. (Min: 1 mL)

Storage/Transport Temperature: Refrigerated.

Remarks: Vaginal specimens are not recommended due to limited clinical correlative data.

Unacceptable Conditions: Specimens in any transport media other than indicated above
Urethral swabs. For specimens in ThinPrep® Pap Test transport media, refer to test code 0060750; for specimens in SurePath® Pap specimen transport media, refer to test code 0060744. Specimens other than cervical are not acceptable for children under age 13.


Stability (collection to initiation of testing): Digene transport medium: Ambient: 2 weeks; Refrigerated: 3 weeks; Frozen: 3 months
Reference Interval:
Negative
 
Test Number Components Reference Interval
 Human Papillomavirus (HPV) DNA Probe, High Risk Only  Negative

Interpretive Data: A high-risk HPV test detects HPV genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68, which are associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur.  Results should be correlated with cytologic/histologic findings.  Sensitivity may be affected by cellularity of specimen.
Note: A negative result does not rule out the presence of an HPV genotype absent from the test panel, a low level infection, or specimen sampling error. 
CPT Code(s): 87621
Cross References: Condyloma (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene)), Genital Warts (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene)), HPV High-Risk (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene)), Hybrid Capture (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene))
 
 

 

 

 
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