ARUP's Laboratory Test Directory

Parvovirus B19 Antibodies Seroconversion, IgG and IgM : 0065109

Mnemonic: PARVO SERO

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Sun-Sat
Reported: 1-3 days
Specimen Required: Collect: Serum separator tube (acute) AND serum separator tube (convalescent). Also acceptable: Lavender (EDTA) or green (sodium or lithium heparin).

Specimen Preparation: Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum or plasma (acute) AND 0.5 mL serum or plasma (convalescent) to individual ARUP Standard Transport Tubes. (Min: 0.3 mL each) If acute specimen was previously tested by ARUP, convalescent specimen must be submitted within 30 days if seroconversion comparison testing is desired. Mark specimens plainly as "acute" or "convalescent" with appropriate draw dates.

Storage/Transport Temperature: Refrigerated..

Remarks: Testing will not be performed unless both acute and convalescent specimens are available.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 5 days; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
 Parvovirus B19 Antibody, IgG Acute 0.89 IV or less: Negative - No significant level of detectable Parvovirus B19 IgG antibody.
0.90-1.10 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to Parvovirus B19 detected which may indicate a current or past infection.
 Parvovirus B19 Antibody, IgG Convalescent 0.89 IV or less: Negative - No significant level of detectable Parvovirus B19 IgG antibody.
0.90-1.10 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to Parvovirus B19 detected which may indicate a current or past infection.
 Parvovirus B19 Antibody, IgM Acute 0.89 IV or less: Negative - No significant level of detectable Parvovirus B19 IgM antibody.
0.90-1.10 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgM antibody to Parvovirus B19 detected which may indicate a current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
 Parvovirus B19 Antibody, IgM Convalescent 0.89 IV or less: Negative - No significant level of detectable Parvovirus B19 IgM antibody.
0.90-1.10 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgM antibody to Parvovirus B19 detected which may indicate a current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
 
CPT Code(s): 86747 x4
Cross References: B19 (Parvovirus B 19 Antibodies Seroconversion, IgG & IgM), Fifth Disease (Parvovirus B 19 Antibodies Seroconversion, IgG & IgM)