#ExistRefRange>Effective May 16, 2011
Susceptible, intermediate, SDD (susceptible dose dependent), or resistant. Interpretive guidelines are provided only for Candida species.
MICs (minimum inhibitory concentrations) without interpretative guidelines are reported for yeast species other than Candida.
MECs (minimum effective concentration) are not reported for yeast species.
#ExistInterpData>SDD = susceptibility is dose dependent.
NONE = Interpretive guidelines are not available
For amphotericin B, there are no CLSI breakpoints, but MIC greater than 1 is considered resistant.
For fluconazole the guidelines are based on experience with mucosal and invasive infections due to Candida species. When the isolate is C. glabrata and the MIC is less than or equal to 32 µg/mL the maximum dosage regimen should be used.
5-fluorocytosine MIC breakpoints are based largely on historical data and partially on the drug's pharmacokinetics.
For itraconazole, the data are based entirely on experience with mucosal infections, and data supporting breakpoints for invasive infections due to Candida spp. are not available.
Voriconazole MIC interpretation is used as surrogate for posaconazole interpretation.
SDD (susceptible dose dependent) applies to fluconazole, itraconazole, posaconazole, and voriconazole. Susceptibility is dependent on achieving the maximum possible level.
For anidulafungin, caspofungin, and micafungin, the data are based substantially on experience with non-neutropenic patients with candidemia. Clinical relevance in other settings is uncertain.
Susceptibility testing is performed by CLSI-approved broth microdilution method.
||The following agents will be tested: Amphotericin B, anidulafungin, caspofungin, fluconazole, 5-fluorocytosine, itraconazole, micafungin, posaconazole, and voriconazole. Candida species, Cryptococcus, Geotrichum and Trichosporon species are tested at ARUP.
If species identification is not provided, identification will be performed at ARUP for an additional charge.
||Yeast Susceptibility Panel (Antimicrobial Susceptibility - Yeast Susceptibility)