ARUP's Laboratory Test Directory
| 0060227: Antimicrobial Susceptibility - Mould Susceptibility |
| Test Mnemonic: MA MOULD | |
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Methodology: Broth Microdilution
Performed: Sun-Sat Reported: 3-12 days |
| Specimen Required: | |
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Collect: Viable mould in pure culture on fungal medium slant. Indicate isolate identification and specimen source. Aspergillus species are tested at ARUP.
Transport: Viable mould in a sealed container at 20-25°C. Submit specimen according to Biological Substance, Category B, shipping guidelines. Pediatric Collection/Transport: Submit specimen according to Biological Substance, Category B, shipping guidelines. Unacceptable Conditions: Nonviable moulds, mixed cultures, leaking containers, or agar plates. Stability: Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: Unacceptable |
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| Reference Interval: |
| Minimum inhibitory concentration (MIC) without interpretation. |
| Interpretive Data: | |
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Interpretive MIC breakpoints have not been established for mould. Experience to date indicates that amphotericin B MICs for most opportunistic mould isolates cluster between 0.5-2.0 µg/mL. However, for some species (e.g., A. terreus) the MIC may range between 2-16 µg/mL. Filamentous fungi are usually not susceptible to 5-fluorocytosine or fluconazole. However, insufficient data are available regarding correlation between MICs and clinical outcome. Susceptibility testing is performed by CLSI-approved broth microdilution method. Please refer to Statement B in the Compliance Statements section in the front of the Laboratory Test Directory. |
| Note: | |
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The following antifungal agents are tested: amphotericin B, 5-fluorocytosine, itraconazole, fluconazole, and voriconazole. Susceptibility testing for Aspergillus species will be performed at ARUP. Testing for all other mould species and antibiotics listed above will be referred to an outside laboratory. Turn around time and price will vary. An additional handling fee will be billed for all organisms submitted that are not in pure culture as indicated in the specimen requirements. |
| CPT Code(s): | |
| 87186 |