ARUP's Laboratory Test Directory

Coxsackie B Virus Antibodies : 0060055

Mnemonic: COX B

Methodology: Semi-Quantitative Serum Neutralization
Performed: Mon-Sat
Reported: 6-9 days
Specimen Required: Collect: Serum separator tube or plain red. OR CSF.

Specimen Preparation: Separate serum from cells within 2 hours of collection. Transfer 1 mL serum or CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
Coxsackie B1: Less than 1:10
Coxsackie B2: Less than 1:10
Coxsackie B3: Less than 1:10
Coxsackie B4: Less than 1:10
Coxsackie B5: Less than 1:10
Coxsackie B6: Less than 1:10
Interpretive Data: Single positive antibody titers of greater than or equal to 1:80 may indicate past or current infection.  Seroconversion or an increase in titers between acute and convalescent sera of at least fourfold is considered strong evidence of current or recent infection.
Note: The clinical significance and criteria for interpretation of results from CSF have not been established.
CPT Code(s): 86658 x6
Cross References: Enterovirus (Coxsackie B Virus Antibodies)