ARUP's Laboratory Test Directory

Thrombotic Risk, DNA Panel : 0056200

Mnemonic: THROMDNA

Ordering Recommendation: Acceptable panel to detect the two most common inherited thrombophilias.
Methodology: Polymerase Chain Reaction
Performed: Sun-Sat
Reported: 2-7 days
Specimen Required: Collect: Lavender (EDTA) or pink (K2 EDTA). Also acceptable: Yellow (ACD Solution A), lt. blue (sodium citrate), or green (sodium or lithium heparin).

Specimen Preparation: Do not freeze. Transport 5 mL whole blood. (Min: 3 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Serum. Frozen specimens. Clotted or severely hemolyzed specimens.

Stability (collection to initiation of testing): Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Reference Interval:
 
Test Number Components Reference Interval
0097720Factor V Leiden (F5) R506Q Mutation Negative: This sample is negative for factor V Leiden, R506Q mutation.
0055655Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations Negative: Neither of the common MTHFR gene mutations tested, C677T and A1298C, were detected.  Other causes of elevated homocysteine levels, coronary heart disease, or thrombosis cannot be excluded. This genotype is associated with a normal folate metabolism.
0056060Prothrombin (F2) G20210A Mutation Negative: This sample is negative for the factor II, prothrombin 20210A mutation.
 
CPT Code(s): 81240, 81241, 81291
Cross References: Hypercoag (Thrombotic Risk, DNA Panel), Hypercoagulable Panel (Thrombotic Risk, DNA Panel), Thrombophilia (Thrombotic Risk, DNA Panel)