ARUP's Laboratory Test Directory

0056009: Tissue Transglutaminase Antibody, IgG

Test Mnemonic: TTG G
Methodology: Enzyme-Linked Immunosorbent Assay

Performed: Mon-Sat

Reported: 1-5 days

Specimen Required:  
Collect: One 4 mL SST.

Transport: 1 mL serum at 2-8°C.  (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Remarks: Remove serum from cells ASAP.

Unacceptable Conditions: Plasma.  Severely lipemic or hemolyzed specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval:
< 20 EU: None Detected
20-30 EU: Weakly Positive
> 30 EU: Positive

Interpretive Data:
The tTG IgG assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency.  A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy. 



Note:
Native human tTG antigen is utilized in this assay

CPT Code(s):
83516