Reference Interval:
| Test Number
| Components
| Reference Interval
| | | bcl-2/JH, t(14;18) Translocation Major Breakpoint Region (MBR), Tissue
| Negative: bcl-2/JH major breakpoint region gene rearrangement is not detected.
Positive: bcl-2/JH major breakpoint region gene rearrangement is detected.
| | | bcl-2/JH, t(14;18) Translocation Minor Cluster Region (MCR), Tissue
| Negative: bcl-2/JH minor cluster region gene rearrangement is not detected.
Positive: bcl-2/JH minor cluster region gene rearrangement is detected.
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| Interpretive Data: |
By report
Please refer to Statement B in the Compliance Statements section in the front of the Laboratory Test Directory.
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| Note: |
A positive result indicates the presence of a bcl-2/JH t(14;18) chromosomal translocation. A negative result does not entirely exclude the presence of a bcl-2/JH chromosomal t(14;18) translocation.
Comment: The chromosomal translocation t(14;18) or bcl-2 gene rearrangement is present in approximately 90% of follicular lymphomas and in a significant minority (10-30%) of diffuse large-cell lymphomas of B-cell lineage. Since most bcl-2 breakpoints cluster at the major breakpoint region (~60%) or minor cluster region (~10%), this PCR assay is capable of detecting a majority of bcl-2/JH gene rearrangements. However, some breakpoints occur at distant loci and will not be identified by this particular test.
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| CPT Code(s): |
83891 Isolation; 83898 x6 Amplification; 83894 x3 Gel separation; 83912 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
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