ARUP's Laboratory Test Directory

Neutrophil-Associated Antibodies : 0055506

Mnemonic: ANTI-NEU

Methodology: Flow Cytometry
Performed: Mon, Wed, Fri
Reported: 1-5 days
Specimen Required: Collect:  One 10 mL plain red or serum separator tube.

Transport:  3 mL serum, frozen (on dry ice). (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube.  For Salt Lake City clients, send 3 mL serum ASAP at 2-8°C.

Pediatric Collection/Transport:  0.5 mL serum, frozen. For Salt Lake City clients, send 0.5 mL serum ASAP at 2-8°C.

Remarks:  Remove serum from cells ASAP.

Stability:  After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Reference Interval:
Negative
Interpretive Data: Neutrophil-associated antibodies may cause neutropenia in various autoimmune disorders including Felty's syndrome, SLE and drug-induced neutropenia.  Febrile transfusion reactions and isoimmune neonatal neutropenia may also be caused by antibodies to neutrophil-specific antigens or HLA antigens.

A positive result on this test is not definitive for specific anti-neutrophil antibodies, since anti-HLA antibodies and immune complexes may also cause a positive result.  The results of this test should be correlated to clinical history and other data.

Please refer to Statement A in the Compliance Statements section in the front of the Laboratory Test Directory.
Note: Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as "weakly positive" and greater than 3 standard deviations as "positive".

This test should not be confused with Anti-Neutrophil Cytoplasmic Antibody, IgG (0050811 - ANCA).
CPT Code(s): 86021
 
 

 

 

 
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