ARUP's Laboratory Test Directory

Soluble Liver Antigen Antibody, IgG : 0055235

Mnemonic: SLA

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Sun, Tue, Thu
Reported: 1-4 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
0.0-20.0 U: Negative
20.1-24.9 U: Equivocal
Greater than or equal to 25.0 U: Positive
Interpretive Data: The presence of SLA antibodies has almost 100% specificity for autoimmune hepatitis, although only 12-30% have these antibodies.  Thus, a negative SLA IgG test does not rule out autoimmune hepatitis.
CPT Code(s): 83516
Cross References: Anti-Liver-Pancreas (LP) (Soluble Liver Antigen Antibody, IgG), Anti-SLA-LP (Soluble Liver Antigen Antibody, IgG), Anti-SLA/LP (Soluble Liver Antigen Antibody, IgG)