ARUP's Laboratory Test Directory
| 0051692: Mannose Binding Lectin |
| Test Mnemonic: MBL | |
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Methodology: Enzyme-Linked Immunosorbent Assay
Performed: Tue Reported: 1-8 days |
| Specimen Required: | |
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Collect: One 3 mL SST, plain red, or green (lithium heparin).
Transport: 1 mL serum or plasma, frozen. (Min 0.3 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.3 mL serum or plasma, frozen. Remarks: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. Separate serum or plasma from cells ASAP. Unacceptable Conditions: Heat-inactivated, refrigerated or contaminated specimens. Stability: After separation from cells: Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 year |
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| Reference Interval: |
| Greater than 50 ng/mL |
| Interpretive Data: | |
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Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis.
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| CPT Code(s): | |
| 83520 |