ARUP's Laboratory Test Directory

Mannose Binding Lectin : 0051692

Mnemonic: MBL

Methodology: Enzyme-Linked Immunosorbent Assay
Performed: Tue
Reported: 1-8 days
Specimen Required: Collect:  One 3 mL serum separator tube, plain red, or green (lithium heparin).

Transport:  1 mL serum or plasma, frozen.  (Min 0.3 mL) Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport:  0.3 mL serum or plasma, frozen.

Remarks:  CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. Separate serum or plasma from cells ASAP.

Unacceptable Conditions:  Heat-inactivated, refrigerated or contaminated specimens.

Stability:  After separation from cells: Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 year
Reference Interval:
Greater than 50 ng/mL
Interpretive Data: Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis.
CPT Code(s): 83520
 
 

 

 

 
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