ARUP's Laboratory Test Directory
| 0051393: Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4) Deficiency Screen |
| Test Mnemonic: IRAK-4 | |
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Methodology: Cell Culture/Multi-Analyte Fluorescence Detection
Performed: Tue-Fri Reported: 2-3 days |
| Specimen Required: | |
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Collect: One 4 mL green (sodium heparin) AND a normal control in one 4 mL green (sodium heparin) from a healthy unrelated individual. Also acceptable: Yellow (ACD solution A).
Transport: 4 mL whole blood AND 4 mL normal control whole blood in sterile containers at 20-25°C. LIVE LYMPHOCYTES REQUIRED. Pediatric Collection/Transport: 2 mL whole blood AND 2 mL normal control whole blood in sterile containers at 20-25°C. LIVE LYMPHOCYTES REQUIRED. Remarks: CRITICAL AMBIENT. Do not refrigerate or freeze. Patient and control specimens must be collected within 48 hours of test performance. Unacceptable Conditions: Refrigerated or frozen specimens. Specimens in transport longer than 48 hours. Stability: Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable |
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| Reference Interval: |
| By report |
| Interpretive Data: | |
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Deficiency in cytokine production in response to stimulation suggests possibility of defect in Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4), which may result in recurrent pneumococcal and/or staphylococcal infections, in absence of other abnormalities of host defense.
Please refer to Statement B in the Compliance Statements section in the front of the Laboratory Test Directory. |
| Note: | |
| Interpretation comparing the patient results to the client normal control, as well as the laboratory control, will be provided by the medical director. |
| CPT Code(s): | |
| 86353 x2 Lymphocyte Transformation; 83520 x3 Cytokine |