ARUP's Laboratory Test Directory

Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4) Deficiency Screen : 0051393

Mnemonic: IRAK-4

Methodology: Cell Culture/Multi-Analyte Fluorescence Detection
Performed: Tue-Fri
Reported: 3-5 days
Specimen Required: Collect: One 4 mL green (sodium heparin) and one normal control in one 4 mL green (sodium heparin) from a healthy unrelated individual. Also acceptable: Yellow (ACD solution A).

Storage/Transport Temperature: 4 mL whole blood and 4 mL normal control in original collection tubes at 20-25°C. (Min: 2 mL whole blood and 2 mL normal control). LIVE LYMPHOCYTES REQUIRED. CRITICAL AMBIENT. Do not refrigerate or freeze.

Remarks: CRITICAL AMBIENT. Do not refrigerate or freeze. Patient and control specimens must be collected within 48 hours of test performance.

Unacceptable Conditions: Refrigerated or frozen specimens. Specimens in transport longer than 48 hours.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
Reference Interval:
By report
Interpretive Data: Deficiency in cytokine production in response to stimulation suggests possibility of defect in Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4), which may result in recurrent pneumococcal and/or staphylococcal infections, in absence of other abnormalities of host defense.

Please refer to Statement B in the Compliance Statements section in the front of the Laboratory Test Directory.
Note: Interpretation comparing the patient results to the client normal control, as well as the laboratory control, will be provided by the medical director.
CPT Code(s): 86353 x2 Lymphocyte Transformation; 83520 x3 Cytokine
 
 

 

 

 
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