ARUP's Laboratory Test Directory

Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4) Deficiency Screen : 0051393
[ image for: Time Sensitive]
Time Sensitive
  


Mnemonic: IRAK-4

Methodology: Cell Culture/Quantitative Multiplex Bead Assay
Performed: Tue-Fri
Reported: 4-9 days
Specimen Required: Patient Prep: Collect control specimen from a healthy individual unrelated to patient.

Collect: Green (sodium heparin) (patient) AND green (sodium heparin) (control). Also acceptable: Yellow (ACD solution A). Patient and control specimens must be collected within 48 hours of test performance.

Specimen Preparation: Transport 4 mL whole blood (patient) AND 4 mL whole blood (control) in original collection tubes. (Min: 2 mL (patient) AND 2 mL (control)) Do not refrigerate or freeze. LIVE LYMPHOCYTES REQUIRED.

Storage/Transport Temperature: CRITICAL ROOM TEMPERATURE.

Remarks:

Unacceptable Conditions: Refrigerated or frozen specimens.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
Reference Interval:
By report
Interpretive Data: Deficiency in cytokine production in response to stimulation suggests possibility of defect in Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4), which may result in recurrent pneumococcal and/or staphylococcal infections, in absence of other abnormalities of host defense.

See Compliance Statement B: www.aruplab.com/CS
Note: Interpretation comparing the patient results to the client normal control, as well as the laboratory control, will be provided by the medical director.
CPT Code(s): 86353 x2; 83520 x3