Platelet Antigen 1 Genotyping (HPA-1) : ARUP Lab Tests

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Platelet Antigen 1 Genotyping (HPA-1) : 0051309

Mnemonic: HPA1

Methodology:	Polymerase Chain Reaction/Fluorescence Monitoring
Performed:	Mon, Thu
Reported:	2-7 days
Specimen Required:	Collect: One 5 mL lavender (EDTA) or pink (K₂EDTA). Also acceptable: yellow (ACD solution A), lt. blue (sodium citrate), or green (sodium or lithium heparin). 10 mL amniotic fluid or two T-25 flasks of 80% confluent amniocytes. Backup cultures must be retained at the client's institution until testing is complete. If the client is unable to culture amniocytes, this can be arranged by contacting ARUP Client Services at (800) 522-2787. Transport: 5 mL whole blood, amniotic fluid, or amniocytes at 20-25°C. (Min: 1 mL) Remarks: Do not freeze. Stability: Ambient: 3 days; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval: By report
Interpretive Data:	Background Information: Incidence: Perinatal alloimmune thrombocytopenia (PAT) occurs in 1 in 5000 births. Characteristics: Spontaneous fetal intracranial bleeding in 20% of severe PAT affected pregnancies; risk of fetal death. Post-transfusion purpura in transfusion recipients with antibodies to a specific platelet antigen. Inheritance: For women homozygous for a rare "b" HPA allele with antibodies to the common "a" allele, there is a 50% risk a pregnancy will be affected if her partner is heterozygous for "a" allele and 100% risk if her partner is homozygous for "a" allele. Mutations tested: HPA a (common) and b (variant) alleles. Limitations: Mutations other than the one examined will not be detected; furthermore, mutations within the primer or probe regions could affect this assay. Sensitivity: 99% Informed consent: Recommended; forms are available at www.aruplab.com. This test is performed pursuant to an agreement with Roche Molecular Systems, Inc. Please refer to Statement C in the Compliance Statements section in the front of the Laboratory Test Directory.
CPT Code(s):	83890 Isolation; 83898 Amplification; 83896 x2 Nucleic acid probes; 83912 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.

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