ARUP's Laboratory Test Directory

0051174: F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer

Test Mnemonic: SMA R
Methodology: Enzyme-Linked Immunosorbent Assay/Indirect Fluorescent Antibody

Performed: Mon-Fri

Reported: 1-6 days

Specimen Required:  
Collect: One 4 mL SST.

Transport: 1 mL serum at 2-8°C.  (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.25 mL serum at 2-8°C. 

Remarks: Separate serum from cells ASAP.

Unacceptable Conditions: Plasma, lipemic, contaminated, hemolyzed, or heat-inactivated specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval:
 
Test Number Components Reference Interval
0055248F-Actin (Smooth Muscle) Antibody, IgG 19 Units or less: Negative
20-30 Units: Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
31 Units or greater: Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis.
0051244Smooth Muscle Antibody, IgG Titer <1:20 = Normal - No antibody detected.
1:20-1:80 = Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
1:160 or greater = Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis.

Interpretive Data:
Refer to report.



Note:
In viral hepatitis the titers are generally less than 1:80 and are transient.  The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

If F-Actin is ³20 Units, then Smooth Muscle Ab, IgG IFA titer will be added.

CPT Code(s):
83516 Actin IgG; if reflexed, add 86256 ASMR Titer

 

 

 
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