ARUP's Laboratory Test Directory

F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer : 0051174

Mnemonic: SMA R

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody
Performed: Sun-Sat
Reported: 1-5 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.25 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval:
 
Test Number Components Reference Interval
0055248F-Actin (Smooth Muscle) Antibody, IgG Effective May 16, 2011
 
19 Units or less Negative
20-30 Units Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
31 Units or greater Positive - Suggestive of autoimmune hepatitis type 1 or chronic active hepatitis.
0051244Smooth Muscle Antibody, IgG Titer <1:20 = Normal - No antibody detected.
1:20-1:80 = Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
1:160 or greater = Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis.

Interpretive Data: Refer to report.
Note: In viral hepatitis the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply
CPT Code(s): 83516; if reflexed, add 86256
Cross References: Actin Antibody Reflexive Panel (F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer) , Anti-Smooth Muscle Antibody (F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer) , ASMA Reflexive Panel (F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer) , F-Actin Antibody Panel (F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer) , SMA Reflexive Panel (F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer) , Smooth Muscle Antibody (F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer) , Soft-SMA (F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer)