Reference Interval:
| Test Number
| Components
| Reference Interval
| | | Neuronal Antibody IgG, Immunoblot Anti-Hu
| Negative
| | | Neuronal Antibody IgG, Immunoblot Anti-Ri
| Negative
| | | Neuronal Antibody IgG, Immunoblot Anti-Yo
| Negative
| | | Neuronal Antibody IgG, Immunoblot Amphiphysin
| Negative
|
|
| Interpretive Data: |
Anti-Hu, type I anti-neuronal nuclear (ANNA-1) is associated with small cell lung cancer. Anti-Ri, type II anti-neuronal nuclear (ANNA-2) is associated with neuroblastoma (children) and fallopian tube or breast cancer (adults). Anti-Yo, anti-purkinje cell cytoplasmic antibodies (PCCA or PCA-1) is associated with ovarian and breast carcinomas.
The presence of one or more of these antibodies supports the clinical diagnosis of paraneoplastic syndrome and leads to a focused search for underlying neoplasm. These markers aid in the discrimination between true paraneoplastic disorders and other inflammatory disorders of the nervous system.
Amphiphysin antibodies are present in about 5% of patients with stiff person syndrome and variably in other paraneoplastic neurological syndrome (PNS) cases. Amphiphysin antibodies are mostly associated with small cell lung cancer (SCLC) and breast tumors.
Refer to Statement D under Testing Information at http://www.aruplab.com.
|
| CPT Code(s): |
83516
|
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