ARUP's Laboratory Test Directory
| 0051090: Neuronal Antibodies (Hu, Ri, Yo, Amphiphysin) IgG by Immunoblot |
| Test Mnemonic: NEURONAL | |
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Methodology: Immunoblot
Performed: Thu Reported: 1-8 days |
| Specimen Required: | |
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Collect: One 4 mL SST.
Transport: 1 mL serum, frozen. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.5 mL serum, frozen. Remarks: Separate serum from cells ASAP. Unacceptable Conditions: Lipemic, hemolyzed, contaminated or heat-inactivated specimens. Plasma. Stability: After separation from cells: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 1 year |
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| Reference Interval: | |||||||||||||||
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| Interpretive Data: | |
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Anti-Hu, type I anti-neuronal nuclear (ANNA-1) is associated with small cell lung cancer. Anti-Ri, type II anti-neuronal nuclear (ANNA-2) is associated with neuroblastoma (children) and fallopian tube or breast cancer (adults). Anti-Yo, anti-purkinje cell cytoplasmic antibodies (PCCA or PCA-1) is associated with ovarian and breast carcinomas. The presence of one or more of these antibodies supports the clinical diagnosis of paraneoplastic syndrome and leads to a focused search for underlying neoplasm. These markers aid in the discrimination between true paraneoplastic disorders and other inflammatory disorders of the nervous system. Amphiphysin antibodies are present in about 5% of patients with stiff person syndrome and variably in other paraneoplastic neurological syndrome (PNS) cases. Amphiphysin antibodies are mostly associated with small cell lung cancer (SCLC) and breast tumors. Please refer to Statement D in the Compliance Statements section in the front of the Laboratory Test Directory. |
| CPT Code(s): | |
| 83516 |