ARUP's Laboratory Test Directory
| 0051088: Neuronal Nuclear Antibodies (ANNA) IgG, Immunoblot, Serum |
| Test Mnemonic: ANNAG IB | |
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Methodology: Immunoblot
Performed: Thu Reported: 1-8 days |
| Specimen Required: | |
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Collect: One 4 mL SST. Also acceptable: lavender (EDTA), pink (K2EDTA), or lt. blue (sodium citrate).
Transport: 1 mL serum, frozen. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.5 mL serum, frozen. Remarks: Separate serum or plasma from cells ASAP. Unacceptable Conditions: Lipemic, hemolyzed, contaminated, or heat-inactivated specimens. Stability: After separation from cells: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 1 year |
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| Reference Interval: | |||||||||
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| Interpretive Data: | |
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ANNA-1 (anti-Hu) and ANNA-2 (anti-Ri) are confirmed by immunoblot detection of antibody reactive with a 35-40 kDa (ANNA-1) or a 55 kDa (ANNA-2) neuronal protein. ANNA-1 is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC). ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy. Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC. ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable.
Please refer to Statement D in the Compliance Statements section in the front of the Laboratory Test Directory. |
| CPT Code(s): | |
| 83516 |