ARUP's Laboratory Test Directory

Neuronal Nuclear Antibodies (ANNA) IgG, Immunoblot, Serum : 0051088

Mnemonic: ANNAG IB

Methodology: Immunoblot
Performed: Thu
Reported: 1-8 days
Specimen Required: Collect: One 4 mL serum separator tube. Also acceptable: lavender (EDTA), pink (K2EDTA), or lt. blue (sodium citrate).

Storage/Transport Temperature: 1 mL serum, frozen. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube.

Remarks: Separate serum or plasma from cells ASAP.

Unacceptable Conditions: Lipemic, hemolyzed, contaminated, or heat-inactivated specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 1 year
Reference Interval:
Test Number Components Reference Interval
Neuronal Nuclear Antibody IgG, Immunoblot Anti-Hu Negative
Neuronal Nuclear Antibody IgG, Immunoblot Anti-Ri Negative

Interpretive Data: ANNA-1 (anti-Hu) and ANNA-2 (anti-Ri) are confirmed by immunoblot detection of antibody reactive with a 35-40 kDa (ANNA-1) or a 55 kDa (ANNA-2) neuronal protein. ANNA-1 is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC). ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy. Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC. ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable.

Please refer to Statement D in the Compliance Statements section in the front of the Laboratory Test Directory.
CPT Code(s): 83516
 
 

 

 

 
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