Reference Interval:
| Test Number
| Components
| Reference Interval
| | | Neuronal Nuclear Antibody IgG, Immunoblot Anti-Hu
| Negative
| | | Neuronal Nuclear Antibody IgG, Immunoblot Anti-Ri
| Negative
|
|
| Interpretive Data: |
ANNA-1 (anti-Hu) and ANNA-2 (anti-Ri) are confirmed by immunoblot detection of antibody reactive with a 35-40 kDa (ANNA-1) or a 55 kDa (ANNA-2) neuronal protein. ANNA-1 is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC). ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy. Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC. ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable.
Refer to Statement D under Testing Information at http://www.aruplab.com.
|
| CPT Code(s): |
83516
|
|