ARUP's Laboratory Test Directory

Neuronal Nuclear Antibodies (ANNA) IgG, Immunoblot, Serum : 0051088

Mnemonic: ANNAG IB

Methodology: Immunoblot
Performed: Thu
Reported: 1-8 days
Specimen Required: Collect:  One 4 mL serum separator tube. Also acceptable: lavender (EDTA), pink (K2EDTA), or lt. blue (sodium citrate).

Transport:  1 mL serum, frozen. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport:  0.5 mL serum, frozen.

Remarks:  Separate serum or plasma from cells ASAP.

Unacceptable Conditions:  Lipemic, hemolyzed, contaminated, or heat-inactivated specimens.

Stability:  After separation from cells: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 1 year
Reference Interval:
 
Test Number Components Reference Interval
 Neuronal Nuclear Antibody IgG, Immunoblot Anti-Hu Negative
 Neuronal Nuclear Antibody IgG, Immunoblot Anti-Ri Negative

Interpretive Data: ANNA-1 (anti-Hu) and ANNA-2 (anti-Ri) are confirmed by immunoblot detection of antibody reactive with a 35-40 kDa (ANNA-1) or a 55 kDa (ANNA-2) neuronal protein.  ANNA-1 is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC).  ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy.  Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC.  ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable.

Please refer to Statement D in the Compliance Statements section in the front of the Laboratory Test Directory.
CPT Code(s): 83516
 
 

 

 

 
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