ARUP's Laboratory Test Directory

Celiac Disease Reflexive Panel : 0051065

Mnemonic: CELIAC TTG

Ordering Recommendation: Preferred reflexive screening panel for celiac disease. Panel includes IgA levels with reflex to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP) (IgA or IgG testing based on initial IgA level).
Methodology: Quantitative Nephelometry/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Sun-Sat
Reported: 2-3 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Remarks: Specify age of patient on test request form.

Unacceptable Conditions: Plasma. Contaminated, hemolyzed, or grossly lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 8 hours; Refrigerated: 8 days; Frozen: 1 year (if frozen within 24 hours)
Reference Interval:
 
Test Number Components Reference Interval
0050340Immunoglobulin A  
 
0-30 days: 1-7 mg/dL
1 month: 1-53 mg/dL
2 months: 3-47 mg/dL
3 months: 5-46 mg/dL
4 months: 4-72 mg/dL
5 months: 8-83 mg/dL
6 months: 8-67 mg/dL
7-8 months: 11-89 mg/dL 		9-11 months: 16-83 mg/dL
1 year: 14-105 mg/dL
2 years: 14-122 mg/dL
3 years: 22-157 mg/dL
4 years: 25-152 mg/dL
5-7 years: 33-200 mg/dL
8-9 years: 45-234 mg/dL
10 years and older: 68-378 mg/dL
0097709Tissue Transglutaminase (tTG) Antibody, IgA 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Moderate to Strong Positive
0056009Tissue Transglutaminase Antibody, IgG < 20 EU: None Detected
20-30 EU: Weakly Positive
> 30 EU: Positive
0051357Deamidated Gliadin Peptide (DGP) Antibody, IgA 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive
0051359Deamidated Gliadin Peptide (DGP) Antibody, IgG 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive

Interpretive Data: Refer to individual components.
Note: If IgA is less than 7 mg/dL, then tTG IgG and Gliadin Peptide IgG will be added. If IgA is greater than or equal to 7 mg/dL, then tTG IgA and Gliadin Peptide IgA will be added. Additional charges apply.
CPT Code(s): 82784; if reflexed, add 83516 x2
82784 IgA; if less than 7 mg/dL, add 83516 tTG IgG and 83516 Gliadin IgG.  If IgA is greater than or equal to 7 mg/dL, add  83516 tTG IgA and 83516 Gliadin IgA
Cross References: Celiac Sprue (Celiac Disease Reflexive Panel), Gluten Sensitivity (Celiac Disease Reflexive Panel)