ARUP's Laboratory Test Directory

0051060: Celiac Disease Panel with Reflex to Titer

Test Mnemonic: CELIAC R
Methodology: Nephelometry/Indirect Fluorescent Antibody/Enzyme-Linked Immunosorbent Assay

Performed: Sun-Sat

Reported: 2-5 days

Specimen Required:  
Collect: One 4 mL SST.  Specify age of patient on test request form.

Transport: 2 mL serum at 2-8°C.  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 1 mL of serum at 2-8°C.

Remarks: Separate from serum ASAP.

Unacceptable Conditions: Plasma. Hemolyzed, grossly lipemic, or contaminated specimens.

Stability: After separation from cells: Ambient: 8 hours; Refrigerated: 8 days; Frozen: 1 year (if frozen within 24 hours)

Reference Interval:
 
Immunoglobulin A, Serum 0-30 days: 1-7 mg/dL                       
1 month: 1-53 mg/dL                                   
2 months: 3-47 mg/dL                                 
3 months: 5-46 mg/dL                             
4 months: 4-72 mg/dL                             
5 months: 8-83 mg/dL                                 
6 months: 8-67 mg/dL                             
7-8 months: 11-89 mg/dL
9-11 months: 16-83 mg/dL
1 year: 14-105 mg/dL
2 years: 14-122 mg/dL
3 years: 22-157 mg/dL
4 years: 25-152 mg/dL
5-7 years: 33-200 mg/dL
8-9 years: 45-234 mg/dL
10 years and older: 68-378 mg/dL
Endomysial Antibody, IgA Screen None detected
Endomysial Antibody, IgA Titer <1:10
Tissue Transglutaminase Antibody, IgG by ELISA < 20 EU: None detected
20-30 EU: Weakly positive
> 30 EU: Positive
Gliadin Peptide Antibody, IgA 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive
Gliadin Peptide Antibody, IgG 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive

Interpretive Data:
Refer to individual components.



Note:
If IgA < 7 mg/dL, then tTG IgG will be added. If tTG IgG is < 20 U and patient is < 3 years of age, then Gliadin Peptide IgG & IgA will be added.
If IgA is ³ 7 mg/dL, then tTG IgA will be added. If tTG IgA is positive, then EMA IFA titer will be added. If tTG IgA is negative and patient is < 3 years of age, then Gliadin Peptide IgG & IgA will be added.

CPT Code(s):
82784 IgA; if < 7 mg/dL, add 83516 tTG IgG; if negative and patient is < 3 years of age, add 83516 x2 Gliadin IgG & IgA.  If IgA is greater than or equal to 7, add 83516 EMA; if EMA is positive, add 86256 EMA Titer