ARUP's Laboratory Test Directory
| 0051000: Glomerular Basement Membrane Antibody, IgG by Multi-Analyte Fluorescent Detection |
| Test Mnemonic: GBM-G ELIS | |
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Methodology: Multi-Analyte Fluorescent Detection
Performed: Sun-Sat Reported: 1-2 days |
| Specimen Required: | |
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Collect: One 4 mL SST.
Transport: 1 mL serum at 2-8°C. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.15 mL serum at 2-8°C. Remarks: Separate serum from cells ASAP. Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) |
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| Reference Interval: |
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Negative: 19 AU/mL or less Equivocal: 20-25 AU/mL Positive: 26 AU/mL or greater |
| Interpretive Data: | |
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The presence of anti-glomerular basement membrane (GBM) antibodies by multi-analyte fluorescent detection (MAFD) may aid in the diagnosis of Goodpasutre syndrome. False positive results may occur due to reactivity against other chains of type IV collagen. If MAFD is negative but there is strong suspicion for disease, renal biopsy may be indicated. A renal biopsy may also be essential in suspected Goodpasture disease with renal involovement, allowing diagnostic confirmation and assesssment of renal prognosis.
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| CPT Code(s): | |
| 83516 |