ARUP's Laboratory Test Directory

0051000: Glomerular Basement Membrane Antibody, IgG by Multi-Analyte Fluorescent Detection

Test Mnemonic: GBM-G ELIS
Methodology: Multi-Analyte Fluorescent Detection

Performed: Sun-Sat

Reported: 1-2 days

Specimen Required:  
Collect: One 4 mL SST.

Transport: 1 mL serum at 2-8°C. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.15 mL serum at 2-8°C.

Remarks: Separate serum from cells ASAP.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater

Interpretive Data:
The presence of anti-glomerular basement membrane (GBM) antibodies by multi-analyte fluorescent detection (MAFD) may aid in the diagnosis of Goodpasutre syndrome.  False positive results may occur due to reactivity against other chains of type IV collagen.  If MAFD is negative but there is strong suspicion for disease, renal biopsy may be indicated.  A renal biopsy may also be essential in suspected Goodpasture disease with renal involovement, allowing diagnostic confirmation and assesssment of renal prognosis.



CPT Code(s):
83516

 

 

 
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