Reference Interval:
0.8 IV or less: Negative - No significant level of Treponema pallidum IgM antibody detected.
0.9-1.1 IV: Equivocal - Questionable presence of Treponema pallidum IgM antibody detected. Repeat testing 10-14 days may be helpful.
1.2 IV or greater: Positive - Presence of IgM antibody to Treponema pallidum detected, suggestive of current or recent infection.
|
| Interpretive Data: |
Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are performed in the same laboratory at the same time. IgM testing is a useful diagnostic aid in differentiating between maternally derived IgG antibodies which cross the placenta, from the IgM antibodies of an active infection in the newborn. In IgM testing for congenital syphilis, the sensitivity is 80%. Therefore, a negative IgM does not necessarily rule out the possibility of congenital syphilis.
Refer to Statement D under Testing Information at http://www.aruplab.com.
|
| CPT Code(s): |
86780
|
Cross References: |
Syphilis Antibody (Treponema pallidum Antibody, IgM by ELISA)
|