ARUP's Laboratory Test Directory

Neuronal Nuclear Antibody (ANNA) Titer IgG by IFA, Serum : 0050912

Mnemonic: ANNAGIFA

Methodology: Indirect Fluorescent Antibody
Performed: Wed
Reported: 1-9 days
Specimen Required: Collect: One 4 mL serum separator tube.

Storage/Transport Temperature: 1 mL serum, frozen. (Min: 0.15 mL) Submit specimen in an ARUP Standard Transport Tube.

Remarks: Separate serum from cells ASAP.

Unacceptable Conditions: Severely lipemic, contaminated, heat-inactivated, or hemolyzed specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
< 1:10 No antibody detected.
Interpretive Data: A titer of greater than or equal to 1:10 indicates antibody was detected to either ANNA-1 (anti-Hu) or ANNA-2 (anti-Ri). An immunoblot assay should be completed for confirmation of ANNA-1 or ANNA-2.

Please refer to Statement D in the Compliance Statements section in the front of the Laboratory Test Directory.
Note: Titers of greater than or equal to 1:10 indicate antibody was detected to either ANNA-1 (anti-Hu) or ANNA-2 (anti-Ri) and will be titered to endpoint.  This test is used primarily for titering patient sera that have previously been confirmed as positive for either ANNA-1 or ANNA-2 by immunoblot.  Only an immunoblot can differentiate between ANNA-1 and ANNA-2.
CPT Code(s): 86256
 
 

 

 

 
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