Reference Interval:
| Test Number
| Components
| Reference Interval
| | 0097709 | Tissue Transglutaminase Antibody (tTG), IgA
| 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Moderate to Strong Positive
| | 0050736 | Endomysial Antibody, IgA by IFA
| Less than 1:10
|
|
| Interpretive Data: |
Tissue Transglutaminase Antibody, IgA: The presence of tissue transglutaminase (tTG) IgA antibody may suggest the possibility of certain gluten-sensitive enteropathies such as celiac disease and dermatitis herpetiformis.
Endomysial Antibody, IgA Titer: The endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase.
|
| Note: |
IgA class endomysial antibody is seen in gluten-sensitive enteropathies. Approximately 70% of patients with dermatitis herpetiformis and almost 100% of patients with active celiac disease will demonstrate IgA antibody. This antibody generally decreases or becomes negative in patients on gluten-free diets and will usually reappear upon gluten challenge.
Endomysial antibody (EMA) is screened using an ELISA tissue transglutaminase (tTG) assay. If tTG IgA is 20 units or greater, then EMA titer will be added. All positives are titered to endpoint. Additional charges apply.
|
| CPT Code(s): |
83516 tTG IgA; if reflexed, add 86256 EMA titer
|
Cross References: |
Celiac disease (Tissue Transglutaminase (tTG) Antibody, IgA with Reflex to Endomysial Antibody, IgA), Endomysial Antibody, IgA (Tissue Transglutaminase (tTG) Antibody, IgA with Reflex to Endomysial Anti, Gluten sensitivity (Tissue Transglutaminase (tTG) Antibody, IgA with Reflex to Endomysial Antibody, |