ARUP's Laboratory Test Directory

Streptococcus pneumoniae Antibodies, IgG (14 serotypes) : 0050725

Mnemonic: PNEUMO AB

Methodology: Quantitative Multiplex Bead Assay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube. Post-immunization specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of pre-immunization specimen.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) MARK SPECIMENS CLEARLY AS "PRE" OR "POST" SO SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY.

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Interpretive Data: Long-term protection is generally thought to be associated with a one month post-vaccine response of at least 1 µg/mL in children and adults.  Responder status is determined, once reaching the minimum level of 1 µg/mL, according to the ratio of postvaccination to prevaccination concentration of pneumococcal IgG antibody as follows:

A ratio of less than twofold is considered a nonresponder.
A ratio of two- to fourfold is a weak responder.
A ratio of fourfold or greater is a good responder.
CPT Code(s): 86317 x14
Cross References: Immune Response (Streptococcus pneumoniae Antibodies, IgG (14 serotypes)) , Pneumococcal Antibodies (Streptococcus pneumoniae Antibodies, IgG (14 serotypes)) , Streptococcus pneumoniae Immune Response (Streptococcus pneumoniae Antibodies, IgG (14 serotypes)) , Streptococcus pneumoniae Vaccine Response (Streptococcus pneumoniae Antibodies, IgG (14 serotypes)) , Vaccine Response (Streptococcus pneumoniae Antibodies, IgG (14 serotypes))