Reference Interval:
Includes Serotypes 1, 3, 4*, 5, 6B*, 7F, 8, 9N, 9V*, 12F, 14*, 18C*, 19F*, 23F*
All serotypes tested are present in the 23-valent pure polysaccharide pneumococcal vaccine. The serotypes marked with an asterisk are contained in the conjugated pneumococcal vaccine.
This assay is designed to use both "pre" and "post" specimens to assess immune responsiveness to vaccination. This test is not designed to determine protection to Streptococcus pneumoniae based on a single specimen.
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| Interpretive Data: |
Long-term protection is generally thought to be associated with a one month post-vaccine response of at least 1 µg/mL in children and adults. Responder status is determined, once reaching the minimum level of 1 µg/mL, according to the ratio of postvaccination to prevaccination concentration of pneumococcal IgG antibody as follows:
A ratio of less than twofold is considered a nonresponder.
A ratio of two- to fourfold is a weak responder.
A ratio of fourfold or greater is a good responder.
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| CPT Code(s): |
86317 x14
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Cross References: |
Pneumococcal Antibodies, IgG |
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