ARUP's Laboratory Test Directory
| 0050725: Streptococcus pneumoniae Antibodies, IgG (14 serotypes) |
| Test Mnemonic: PNEUMO AB | |
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Methodology: Multi-Analyte Fluorescent Detection
Performed: Mon, Thu, Sat Reported: 1-4 days |
| Specimen Required: | |
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Collect: One 4 mL SST.
Transport: 1.5 mL serum at 2-8°C. (Min: 0.7 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.15 mL serum at 2-8°C. Remarks: Separate serum from cells ASAP. "Pre" and "post" pneumococcal vaccine specimens can be submitted separately or together for testing. "Post" specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of "pre" specimen. PLEASE CLEARLY MARK SPECIMENS "PRE-VACCINE" OR "POST-VACCINE" SO THAT SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY. Unacceptable Conditions: Plasma or other body fluids. Severely lipemic, contaminated, or hemolyzed specimens. Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) |
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| Reference Interval: |
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Includes Serotypes 1, 3, 4*, 5, 6B*, 7F, 8, 9N, 9V*, 12F, 14*, 18C*, 19F*, 23F* All serotypes tested are present in the 23-valent pure polysaccharide pneumococcal vaccine. The serotypes marked with an asterisk are contained in the conjugated pneumococcal vaccine. This assay is designed to use both "pre" and "post" samples to assess immune responsiveness to vaccination. This test is not designed to determine protection to Streptococcus pneumoniae based on a single sample. |
| Interpretive Data: | |
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Long-term protection is generally thought to be associated with a one month post-vaccine response of 1 µg/mL in children and adults. Responder status is determined according to the ratio of postvaccination to prevaccination concentration of pneumococcal IgG antibody as follows: A ratio of less than twofold is considered a nonresponder. A ratio of two- to fourfold is a weak responder. A ratio of fourfold or greater is a good responder. A response to greater than 50% of the antigens contained in the vaccination is most likely indicative of a normal response. |
| CPT Code(s): | |
| 86317 x14 |