ARUP's Laboratory Test Directory

Centromere Antibody, IgG : 0050714

Mnemonic: ANTICENT

Methodology: Multi-Analyte Fluorescent Detection
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect:  One 4 mL serum separator tube.

Transport:  1 mL serum at 2-8°C. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport:  0.1 mL serum at 2-8°C.

Remarks:  Separate serum from cells ASAP.

Unacceptable Conditions:  Plasma.  Severely lipemic, contaminated, or hemolyzed specimens.

Stability:  After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Interpretive Data: Centromere antibody is present in 80-90% of individuals with CREST variant scleroderma. This antibody is also seen in 30% of Raynaud patients, 12% of patients with mixed connective-tissue disease, diffuse scleroderma, interstitial pulmonary fibrosis, primary biliary cirrhosis, and in a smaller percent of patients with systemic lupus erythematosus (SLE) and RA. 
CPT Code(s): 86039
 
 

 

 

 
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