ARUP's Laboratory Test Directory

Coccidioides Antibodies Panel, CSF by CF, ID, ELISA : 0050710

Mnemonic: COCCI CSF

Methodology: Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Refer to individual components
Reported: 2-5 days
Specimen Required: Collect: CSF.

Specimen Preparation: Transfer two 1 mL aliquots of CSF to individual ARUP Standard Transport Tubes. (Min: 0.3 mL per aliquot)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Grossly bloody or hemolyzed specimens.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
0050170Coccidioides Antibody by CF < 1:2
0050183Coccidioides Antibody by ID None detected.
0050179Coccidioides Antibody, IgG by ELISA 0.9 IV or less: Negative- No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
0050178Coccidioides Antibody, IgM by ELISA 0.9 IV or less: Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data: Refer to individual components.
Note: Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10% of patients with coccidioidal meningitis will not have antibody in CSF.  Negative fungal serology does not rule out the possibility of current infection.
CPT Code(s): 86635 x4
Cross References: San Joaquin Fever Antibodies (Coccidioides Antibodies Panel, CSF by CF, ID, ELISA) , Valley Fever (Coccidioides Antibodies Panel, CSF by CF, ID, ELISA)