ARUP's Laboratory Test Directory

0050710: Coccidioides Antibodies Panel, CSF by CF, ID, ELISA

Test Mnemonic: COCCI CSF
Methodology: Complement Fixation/Immunodiffusion/Enzyme-Linked Immunosorbent Assay

Performed: Sun-Fri

Reported: 2-5 days

Specimen Required:  
Collect: CSF.

Transport: Two 1 mL aliquots of CSF at 2-8°C. (Min: 0.5 mL per aliquot)  Submit specimen in two ARUP Standard Transport Tubes.

Pediatric Collection/Transport: 0.3 mL aliquot of CSF at 2-8°C.

Unacceptable Conditions: Grossly bloody or hemolyzed specimens.

Stability: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
 
Test Number Components Reference Interval
0050170Coccidioides Antibody by CF < 1:2
0050183Coccidioides Antibody by ID None detected.
0050179Coccidioides Antibody, IgG by ELISA 0.9 IV or less: Negative- No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
0050178Coccidioides Antibody, IgM by ELISA 0.9 IV or less: Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data:
Refer to individual components.



Note:
Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10% of patients with coccidioidal meningitis will not have antibody in CSF.  Negative fungal serology does not rule out the possibility of current infection.

CPT Code(s):
86635 Cocci Ab (CF); 86635 Cocci Ab (ID); 86635 Cocci IgG (EIA); 86635 Cocci IgM (EIA)

 

 

 
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