ARUP's Laboratory Test Directory

MPO/PR-3 (ANCA) Antibodies : 0050707

Mnemonic: MPO/PR3

Methodology: Semi-Quantitative Multi-Analyte Fluorescent Detection
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
0050526Myeloperoxidase Antibody Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater
0050527Serine Protease 3 Antibody Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater

Interpretive Data: Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO. 
Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.
CPT Code(s): 83516 Myeloperoxidase Ab; 83516 Serine Protease 3
Cross References: ANCA Antibodies (MPO/PR3) by ELISA (MPO/PR-3 (ANCA) Antibodies), ANCA Antibody (MPO/PR-3 (ANCA) Antibodies), Myeloperoxidase Antibodies (MPO/PR-3 (ANCA) Antibodies), Proteinase 3 Antibodies (MPO/PR-3 (ANCA) Antibodies)
 
 

 

 

 
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