ARUP's Laboratory Test Directory

MPO/PR-3 (ANCA) Antibodies : 0050707

Mnemonic: MPO/PR3

Methodology: Multi-Analyte Fluorescent Detection
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect:  One 4 mL serum separator tube.

Transport:  1 mL serum at 2-8°C. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport:  0.15 mL serum at 2-8°C.

Remarks:  Separate serum from cells ASAP.

Unacceptable Conditions:  Plasma, urine, other body fluids.  Severely lipemic, contaminated, or hemolyzed specimens.

Stability:  After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
0050526Myeloperoxidase Antibody Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater
0050527Serine Protease 3 Antibody Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater

Interpretive Data: Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO. 
Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.
CPT Code(s): 83516 Myeloperoxidase Ab; 83516 Serine Protease 3
 
 

 

 

 
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