ARUP's Laboratory Test Directory

0050707: MPO/PR-3 (ANCA) Antibodies

Test Mnemonic: MPO/PR3
Methodology: Multi-Analyte Fluorescent Detection

Performed: Sun-Sat

Reported: 1-2 days

Specimen Required:  
Collect: One 4 mL SST.

Transport: 1 mL serum at 2-8°C. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.15 mL serum at 2-8°C.

Remarks: Separate serum from cells ASAP.

Unacceptable Conditions: Plasma, urine, other body fluids.  Severely lipemic, contaminated, or hemolyzed specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
 
Test Number Components Reference Interval
0050526Myeloperoxidase Antibody Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater
0050527Serine Protease 3 Antibody Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater

Interpretive Data:
Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO. 
Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.



CPT Code(s):
83516 Myeloperoxidase Ab; 83516 Serine Protease 3

 

 

 
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