ARUP's Laboratory Test Directory

Reticulin Antibody, IgA with Reflex to Titer : 0050698

Mnemonic: RETIC R

Ordering Recommendation: Do not use this obsolete test for celiac disease screening. Preferred screening test is Celiac Disease Reflexive Panel (0051065) or Tissue Transglutaminase (tTG) Antibody, IgA (0097709) for individuals with normal levels of serum IgA.
Methodology: Semi-Quantitative Indirect Fluorescent Antibody
Performed: Mon-Fri
Reported: 1-5 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
 Reticulin Antibody, IgA Screen < 1:5  No antibody detected
 Reticulin Antibody, IgA Titer < 1:5  No antibody detected

Note: IgA class reticulin antibodies are found in dermatitis herpetiformis (25%) and celiac disease (60%), but not in other autoimmune problems. IgG class reticulin antibodies are found in other disease states, especially bullous dermatoses, and sometimes in normal patients.  All positives are titered to endpoint. If Reticulin Antibody is 1:5, then a titer will be added. Additional charges apply.
CPT Code(s): 86255; if reflexed add 86256
Cross References: Anti-Reticulin Antibody (Reticulin Antibody, IgA with Reflex to Titer)