ARUP's Laboratory Test Directory
| 0050599: Scleroderma (Scl-70) (ENA) Antibody, IgG |
| Test Mnemonic: SCLER | |
|
Methodology: Multi-Analyte Fluorescent Detection
Performed: Sun-Sat Reported: 1-2 days |
| Specimen Required: | |
|
Collect: One 4 mL SST.
Transport: 1 mL serum at 2-8°C. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.15 mL serum at 2-8°C. Remarks: Separate serum from cells ASAP. Unacceptable Conditions: Plasma and other body fluids. Severely lipemic, contaminated, and hemolyzed specimens. Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) |
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| Reference Interval: |
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29 AU/mL or less: Negative 30-40 AU/mL: Equivocal 41 AU/mL or greater: Positive |
| Interpretive Data: | |
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Scleroderma (Scl-70) antibody is seen in 20-60% of patients with scleroderma and is considered diagnostic and specific for scleroderma if it is the only ENA antibody present. Scl-70 is also seen in approximately 25% of progressive systemic sclerosis (PSS).
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| CPT Code(s): | |
| 86235 |