ARUP's Laboratory Test Directory

0050588: Coccidioides Antibodies Panel, Serum by CF, ID, ELISA

Test Mnemonic: COCCI PAN
Methodology: Complement Fixation/Immunodiffusion/Enzyme-Linked Immunosorbent Assay

Performed: Sun-Fri

Reported: 2-5 days

Specimen Required:  
Collect: One 4 mL SST.

Transport: Two 1 mL aliquots of serum at 2-8°C. (Min: 0.5 mL per aliquot)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.3 mL serum at 2-8°C.

Remarks: Separate serum from cells ASAP. Acute and convalescent specimens must be labeled as such; parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Please mark specimen plainly as "acute" or "convalescent."

Unacceptable Conditions: Other body fluids and severely lipemic, contaminated, or hemolyzed specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
 
Test Number Components Reference Interval
0050170Coccidioides Antibody by CF < 1:2
0050183Coccidioides Antibody by ID None detected.
0050179Coccidioides Antibody, IgG by ELISA 0.9 IV or less: Negative- No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
0050178Coccidioides Antibody, IgM by ELISA 0.9 IV or less: Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data:
Refer to individual components.



Note:
For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired samples are preferred.  Acute and convalescent samples (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.

CPT Code(s):
86635 Cocci Ab (CF); 86635 Cocci Ab (ID); 86635 Cocci Ab, IgG (EIA); 86635 Cocci Ab, IgM (EIA)

 

 

 
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