ARUP's Laboratory Test Directory

Inflammatory Bowel Disease Differentiation Profile : 0050567

Mnemonic: IBD

Ordering Recommendation: Preferred test for differentiating Crohn disease from ulcerative colitis in inflammatory bowel disease.
Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody
Performed: Refer to individual components
Reported: 1-4 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Available Separately Components Reference Interval
 Saccharomyces cerevisiae Antibody, IgG  20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive
 Saccharomyces cerevisiae Antibody, IgA 20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive
 Anti-Neutrophil Cytoplasmic Antibody, Atypical Pattern < 1:20:  Not significant
 
Interpretive Data: P-ANCA antibodies are found in 50-70% of ulcerative colitis (UC) patients, but in only 20% of Crohn disease (CD) patients.  In contrast, Saccharomyces cerevisiae IgG antibodies are found in 80% of CD patients, but only 20% of UC patients.  Saccharomyces cerevisiae IgA antibodies are found in 35% of CD patients but < 1% in UC patients.
Note: This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
CPT Code(s): 86671 x2; 86255
Cross References: IBD (Inflammatory Bowel Disease Differentiation Profile), IBD Differentiation Profile (Inflammatory Bowel Disease Differentiation Profile)