ARUP's Laboratory Test Directory

0050567: Inflammatory Bowel Disease Differentiation Profile

Test Mnemonic: IBD
Methodology: Enzyme-Linked Immunosorbent Assay/Indirect Fluorescent Antibody

Performed: Refer to individual components

Reported: Refer to individual components

Specimen Required:  
Collect: One 4 mL SST.

Transport: 1.5 mL serum at 2-8°C. (Min: 1 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.5 mL serum at 2-8°C.

Remarks: Separate serum from cells ASAP.

Unacceptable Conditions: Severely lipemic, contaminated, heat-inactivated, or hemolyzed specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
 
Available Separately Components Reference Interval
0050562Saccharomyces cerevisiae Antibody, IgG  £ 20 Units: No Antibody Detected
21-24 Units: Equivocal
³ 25 Units: Positive
0050563Saccharomyces cerevisiae Antibody, IgA £ 20 Units: No Antibody Detected
21-24 Units: Equivocal
³ 25 Units: Positive
 Anti-Neutrophil Cytoplasmic Antibody, Atypical Pattern < 1:20:  Not significant
 

Interpretive Data:
P-ANCA antibodies are found in 50-70% of ulcerative colitis (UC) patients, but in only 20% of Crohn disease (CD) patients.  In contrast, Saccharomyces cerevisiae IgG antibodies are found in 80% of CD patients, but only 20% of UC patients.  Saccharomyces cerevisiae IgA antibodies are found in 35% of CD patients but < 1% in UC patients.



Note:
This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.

CPT Code(s):
86671 x2 Semiquantitative immunoassay-fungus not elsewhere specified; 86255 Fluorescent noninfectious agent antibody screen

 

 

 
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