ARUP's Laboratory Test Directory

Saccharomyces cerevisiae Antibodies, IgG & IgA : 0050564

Mnemonic: SC PAN

Ordering Recommendation: Aids in differentiating Crohn disease from ulcerative colitis in individuals with inflammatory bowel disease. Inflammatory Bowel Disease Differentiation Profile (0050567) is the preferred test.
Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
 Saccharomyces cerevisiae Antibody, IgG  20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive
 Saccharomyces cerevisiae Antibody, IgA 20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive

Interpretive Data: Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.
Note: This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
CPT Code(s): 86671 x2
Cross References: ASCA (Saccharomyces cerevisiae Antibodies, IgG & IgA) , ASCA Abs (Saccharomyces cerevisiae Antibodies, IgG & IgA) , IBD Antibodies (Saccharomyces cerevisiae Antibodies, IgG & IgA)