Reference Interval:
Negative: The specimen is negative for HLA-B27.
Positive: The specimen is positive for HLA-B27.
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| Interpretive Data: |
Background Information for Ankylosing Spondylitis (HLA-B27) Genotyping:
Characteristics: Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily causes pain and inflammation of the joints between the vertebrae of the spine and the sacroiliac joints. Inflammation and pain may occur in other parts of the body as well. HLA-B27 is strongly associated with ankylosing spondylitis (AS) as well as with Reiter syndrome, anterior uveitis, psoriatic arthritis, and inflammatory bowel disease.
Incidence: Greater than 90 percent of patients with AS are HLA-B27 positive compared to 5-10 percent of the general population.
Penetrance: Two to eight percent of individuals with HLA-B27 will develop AS.
Methodology: Polymerase chain reaction (PCR) and fluorescent hybridization probes.
Analytical Sensitivity & Specificity: 99 percent
Limitations: Rare alleles present in less than 1 percent of most populations will not be detected.
This test is performed pursuant to an agreement with Roche Molecular Systems, Inc.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.
See Compliance Statement C: www.aruplab.com/CS
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| CPT Code(s): |
81374
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Cross References: |
HLA-B27 (Ankylosing Spondylitis (HLA-B27) Genotyping) |
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