Reference Interval:
| Test Number
| Components
| Reference Interval
| | | Borrelia burgdorferi Total Antibodies, IgG and/or IgM by ELISA
| These reference intervals are to be used in the interpretation of Borrelia burgdorferi Total Antibodies, IgG and/or IgM by ELISA result:
0.99 LIV or less: Negative - Antibody to Borrelia burgdorferi not detected.
1.00-1.20 LIV: Equivocal - Repeat testing in 10-14 days may be helpful.
1.21 LIV or greater: Positive - Probable presence of antibody to Borrelia burgdorferi detected.
| | 0050255 | Borrelia burgdorferi Antibody, IgG by Western Blot
| Negative
IgG Positive: Any five of the following 10 bands: 18, 23, 28, 30, 39, 41, 45, 58, 66, or 93 kDa.
IgG Negative: Any pattern that does not meet the IgG-positive criteria.
| | 0050253 | Borrelia burgdorferi Antibody, IgM by Western Blot
| Negative
IgM Positive: Any 2 of the following 3 bands: 23, 39, or 41 kDa.
IgM Negative: Any pattern that does not meet the IgM positive criteria.
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| Note: |
This panel is appropriate for Lyme disease testing less than four weeks from erythema migrans or onset of disease symptoms.
A negative result indicates that the Western blot evaluation for Borrelia burgdorferi antibody demonstrates no antibodies unique to Borrelia burgdorferi, and therefore is not supportive of Lyme disease.
A positive result indicates that the Western blot evaluation for Borrelia burgdorferi antibody is consistent with the presence of antibody produced by patients in response to infection by Borrelia burgdorferi and suggests the presence of Lyme disease. Although the test has been shown to have a high degree of reliability for diagnostic purposes, laboratory data should always be correlated with clinical findings.
Current CDC recommendations for the serological diagnosis of Lyme disease are to screen with a polyvalent ELISA test and confirm equivocals and positives with Western blot. Both IgM and IgG Western blots should be performed on samples obtained less than four weeks after appearance of erythema migrans. Only IgG Western blot is to be performed on samples greater than four weeks after disease onset. IgM Western blot in the chronic stage is not recommended and does not aid in the diagnosis of neuroborreliosis or chronic Lyme disease.
If ELISA result is 1.00 LIV, then IgG and IgM Western blot will be added.
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| CPT Code(s): |
86618 B. burgdorferi total Ab. IgG/IgM; if reflexed, add 86617 B. burgdorferi Western blot IgG and 86617 B. burgdorferi Western blot IgM
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