ARUP's Laboratory Test Directory

Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG : 0050225

Mnemonic: EBV EAD

Ordering Recommendation: May aid in the diagnosis of acute Epstein-Barr virus (EBV) infection and EBV reactivation in conjunction with other serologic studies. Molecular tests are preferred to detect EBV reactivation. Not a stand-alone test.
Methodology: Semi-Quantitative Chemiluminescent Immunoassay
Performed: Mon-Sun
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimen plainly as "acute" or "convalescent."

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Tissue or urine. Contaminated or heat-inactivated specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
Effective February 19, 2013

8.9 U/mL or less: Not Detected
9.0-10.9 U/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
11.0 U/mL or greater: Detected
Interpretive Data: Interpretive information regarding serologic features of EBV-associated diseases is available at www.arupconsult.com/ebvdx .
Note: EBV EA-D values obtained with different manufacturers' assay methods may not be used interchangeably.  The magnitude of the reported EBV EA-D level cannot be correlated to an endpoint titer.
CPT Code(s): 86663
Cross References: EBNA Antibody (Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG), EBV Antibody to Early D Antigen (Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG), EBV Nuclear Antibody (Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG), Infectious Mononucleosis (Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG)