Reference Interval:
| Test Number
| Components
| Reference Interval
| | | dsDNA (Double Stranded DNA) Antibody, IgG
| None detected.
| | | dsDNA Antibody, IgG by IFA
| Less than 1:10
|
|
| Interpretive Data: |
dsDNA antibodies are screened using an ELISA assay. If dsDNA antibodies are Detected, then dsDNA Antibody IgG by IFA (using Crithidia luciliae) will be performed.
|
| Note: |
dsDNA antibodies (1:10 or greater) are found in 50-60% of systemic lupus erythematosus (SLE), 20-30% in Sjögren syndrome, 20-25% in mixed connective tissue disease (MCTD), and less than 5% in progressive systemic sclerosis (PSS). High titers of antibody to native (double stranded) DNA are specific for SLE.
|
| CPT Code(s): |
86225 dsDNA ELISA; if reflexed, add 86225 dsDNA IFA
|
Cross References: |
Anti-dsDNA Antibody, IgG, Anti-Native DNA, Crithidia luciliae, DNA Double Stranded Antibody, IgG, Drug Induced SLE, dsDNA (Double Stranded DNA) Antibody, IgG |