ARUP's Laboratory Test Directory
| 0050210: Diphtheria Antibody, IgG |
| Test Mnemonic: DIP | |
|
Methodology: Multi-Analyte Fluorescent Detection
Performed: Mon-Fri Reported: 1-4 days |
| Specimen Required: | |
|
Collect: One 4 mL SST.
Transport: 1 mL serum at 2-8°C. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.15 mL serum at 2-8°C. Remarks: Separate serum from cells ASAP. "Pre" and "post" vaccination specimens should be submitted together for testing. "Post" specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of "pre" specimen. PLEASE CLEARLY MARK SPECIMENS "PRE-VACCINE" OR "POST-VACCINE" SO THAT SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY. Unacceptable Conditions: Plasma or other body fluids. Stability: After separation from the cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) |
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| Reference Interval: |
| Antibody concentration of > 0.1 IU/mL is usually considered protective. |
| Interpretive Data: | |
|
Responder status is determined according to the ratio of a one-month post-vaccination sample to pre-vaccination concentration of diphtheria IgG antibody as follows: 1. If the post-vaccination concentration is less than 1.0 IU/mL, the patient is considered a nonresponder. 2. If the post-vaccination concentration is greater than or equal to 1.0 IU/mL, a patient with a ratio of less than 1.5 is a nonresponder, a ratio of 1.5 to less than 3.0, is a weak responder, and a ratio of 3.0 or greater, is a good responder. 3. If the pre-vaccination concentration is greater than 1.0 IU/mL, it may be difficult to assess the response based on a ratio alone. A post-vaccination concentration above 2.5 IU in this case is usually adequate. |
| CPT Code(s): | |
| 86317 |