ARUP's Laboratory Test Directory

Cryoglobulin, Qualitative with Reflex to Quantitative IgA, IgG, & IgM : 0050187

Mnemonic: CRYGBQNT

Methodology: Nephelometry/Cold Precipitation
Performed: Sun-Sat
Reported: 3-5 days
Specimen Required: Collect:  Whole blood must be drawn in a pre-warmed (37°C) syringe and kept at 37°C. Immediately after blood has been obtained, transfer specimen to a pre-warmed (37°C) plain red and keep specimen at 37°C until clotting is complete. Specimen may be drawn directly into a pre-warmed collection tube and maintained at 37°C until centrifugation. Let clot for one hour at 37°C. Separate serum from cells using a 37°C centrifuge, if possible.  

Transport:  3 mL serum at 20-25°C.  (Min: 3 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport:  1 mL serum at 20-25°C. 

Remarks:  Fasting specimen recommended. Do not refrigerate or freeze at any time. Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay.

Unacceptable Conditions:  Refrigerated or frozen specimens. Separator tubes.  Lipemic or grossly hemolyzed specimen. Plasma

Stability:  After separation from cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable
Reference Interval:
 
Test Number Components Reference Interval
 Cryoglobulin Quantitative Negative at 72 hours
 Immunoglobulin A, Serum None detected
 Immunoglobulin G, Serum None detected
 Immunoglobulin M, Serum None detected

Interpretive Data: The sample is examined daily for the presence or absence of cryoglobulin.
Note: Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.

If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added.
CPT Code(s): 82595 Cryoglobulin; if reflexed, add 82784 x3 (IgA, IgG, IgM)
 
 

 

 

 
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