ARUP's Laboratory Test Directory
| 0050187: Cryoglobulin, Qualitative with Reflex to Quantitative IgA, IgG, & IgM |
| Test Mnemonic: CRYGBQNT | |
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Methodology: Nephelometry/Cold Precipitation
Performed: Sun-Sat Reported: 3-5 days |
| Specimen Required: | |
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Collect: Whole blood must be drawn in a pre-warmed (37°C) syringe and kept at 37°C. Immediately after blood has been obtained, transfer specimen to a pre-warmed (37°C) plain red and keep specimen at 37°C until clotting is complete. Specimen may be drawn directly into a pre-warmed collection tube and maintained at 37°C until centrifugation. Let clot for one hour at 37°C. Separate serum from cells using a 37°C centrifuge, if possible.
Transport: 3 mL serum at 20-25°C. (Min: 3 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 1 mL serum at 20-25°C. Remarks: Fasting specimen recommended. Do not refrigerate or freeze at any time. Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay. Unacceptable Conditions: Refrigerated or frozen specimens. Separator tubes. Lipemic or grossly hemolyzed specimen. Plasma Stability: After separation from cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable |
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| Interpretive Data: | |
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The sample is examined daily for the presence or absence of cryoglobulin.
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| Note: | |
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Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease. If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. |
| CPT Code(s): | |
| 82595 Cryoglobulin; if reflexed, add 82784 x3 (IgA, IgG, IgM) |