ARUP's Laboratory Test Directory

Coccidioides Antibody, IgG by ELISA : 0050179

Mnemonic: COCCI G

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Mon-Fri
Reported: 1-5 days
Specimen Required: Collect: Serum separator tube OR CSF.

Specimen Preparation: Transfer 1 mL serum OR CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
0.9 IV or less: Negative- No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
Interpretive Data: IgG antibodies usually appear by the third week of infection and may persist for years.  Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.
Note: Negative fungal serology does not rule out the possibility of current infection.
CPT Code(s): 86635
Cross References: San Joaquin Fever Antibody (Coccidioides Antibody, IgG by ELISA) , Valley Fever IgG (Coccidioides Antibody, IgG by ELISA)