ARUP's Laboratory Test Directory

0050179: Coccidioides Antibody, IgG by ELISA

Test Mnemonic: COCCI G
Methodology: Enzyme-Linked Immunosorbent Assay

Performed: Mon-Fri

Reported: 1-5 days

Specimen Required:  
Collect: One 4 mL SST or 2 mL CSF.

Transport: 1 mL serum or CSF at 2-8°C. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.15 mL serum or CSF at 2-8°C.

Unacceptable Conditions: Severely lipemic, contaminated, or hemolyzed specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
0.9 IV or less: Negative- No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

Interpretive Data:
IgG antibodies usually appear by the third week of infection and may persist for years.  Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.



Note:
Negative fungal serology does not rule out the possibility of current infection.

CPT Code(s):
86635