ARUP's Laboratory Test Directory
| 0050178: Coccidioides Antibody, IgM by ELISA |
| Test Mnemonic: COCCI M | |
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Methodology: Enzyme-Linked Immunosorbent Assay
Performed: Mon-Fri Reported: 1-5 days |
| Specimen Required: | |
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Collect: One 4 mL SST or 2 mL CSF.
Transport: 1 mL serum or CSF at 2-8°C. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.15 mL serum or CSF at 2-8°C. Remarks: Separate serum from cells ASAP. Acute and convalescent specimens must be labeled as such; parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Please mark specimen plainly as "acute" or "convalescent." Unacceptable Conditions: Severely lipemic, contaminated, or hemolyzed specimens. Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) |
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| Reference Interval: |
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0.9 IV or less: Negative - No significant level of Coccidioides IgM antibody detected. 1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful. 1.5 IV or greater: Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection. |
| Interpretive Data: | |
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In most symptomatic patients, IgM antibodies usually appear by the second week of infection and disappear by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.
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| Note: | |
| Negative fungal serology does not rule out the possibility of current infection. |
| CPT Code(s): | |
| 86635 |