ARUP's Laboratory Test Directory
| 0050165: Cytomegalovirus Antibody, IgG |
| Test Mnemonic: CMV IGG | |
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Methodology: Chemiluminescent Immunoassay
Performed: Sun-Sat Reported: Within 24 hours |
| Specimen Required: | |
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Collect: One 4 mL SST.
Transport: 1 mL serum at 2-8°C. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 0.5 mL serum at 2-8°C. Remarks: Allow specimen to clot completely at room temperature. Separate serum from cells ASAP. Acute and convalescent specimens must be labeled as such; parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Please mark specimen plainly as "acute" or "convalescent." Unacceptable Conditions: Contaminated, hemolyzed, or heat-inactivated specimens. Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) |
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| Reference Interval: |
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0.89 IV or less: Negative - No significant level of detectable CMV IgG antibody. 0.90-1.09 IV: Equivocal - Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive - IgG antibody to CMV detected, which may indicate a current or past CMV infection. |
| Interpretive Data: | |
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In immunocompromised patients, CMV serology (IgG or IgM antibody titers) may not be reliable and may be misleading in the diagnosis of acute or reactivation CMV disease. The preferred method for diagnosis is culture of virus and/or demonstration of viral antigen in peripheral white cells (buffy coat), bronchoalveolar lavage (BAL) cells, or tissue biopsies. The best evidence for current infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time. |
| CPT Code(s): | |
| 86644 |