ARUP's Laboratory Test Directory

0050138: Islet Cell Antibody, IgG

Test Mnemonic: ANTI-ISLET
Methodology: Indirect Fluorescent Antibody

Performed: Mon, Wed, Fri

Reported: 1-3 days

Specimen Required:  
Collect: One 4 mL SST.

Transport: 1 mL serum at 2-8°C. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.15 mL serum at 2-8°C.

Remarks: Separate serum from cells ASAP.

Unacceptable Conditions: Plasma.  Severely lipemic, contaminated, or hemolyzed specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
< 1:4 No antibody detected.

Interpretive Data:
Islet cell antibodies have been associated with "autoimmune" endocrine disorders and insulin-dependent diabetes.  This disorder is characterized by the presence of antibodies in patients that may be detected years before the onset of the clinical symptoms.  To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8  8 x 5 = 40 JDF Units).



CPT Code(s):
86341