Reference Interval:
None detected
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| Interpretive Data: |
ANA specimens are screened using an ELISA assay. All specimens that screen positive or equivocal are confirmed using HEp-2 cells, and if positive, the titer and pattern will be reported.
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| Note: |
When cell culture substrates (HEp-2 cells) are used, the ANA incidence is 99% in systemic lupus erythematosus (SLE), 85% in Sjsyndrome, 88% in scleroderma, 55% in rheumatoid arthritis, and 40% in juvenile rheumatoid arthritis. Specimens are screened for ANA using ELISA. If antibodies are detected, then an IFA titer using HEp-2 cells will be added.
ARUP uses anti-human IgG conjugate since many (20-77%) normal individuals have low levels (1:10 to 1:80) of ANA-IgM. Conversion of ANAs from IgM to IgG generally precedes the onset of autoimmune disease states. If the physician feels that the patient may have an autoimmune disease that is the result of an atypical ANA, please contact the ARUP Immunology Lab to discuss alternative testing.
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| CPT Code(s): |
86038 ANA; if reflexed, add 86039 ANA titer
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