| Ordering Recommendation: |
Effective primary test for Lynch syndrome. Use to determine mismatch repair deficiency and to direct additional molecular diagnostic testing for Lynch syndrome.
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| Methodology: |
Qualitative Immunohistochemistry
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| Performed: |
Mon, Thu
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| Reported: |
Within 5 days
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| Specimen Required: |
Collect: Tumor tissue.
Specimen Preparation: Formalin fix (10 percent neutral buffered formalin is preferred) and paraffin embed specimen. If sending precut slides, do not oven bake. Transport tissue block or 15 unstained (3-5 micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.(Min: 12 slides). Protect paraffin block and/or slides from excessive heat.
Storage/Transport Temperature: Room temperature or refrigerated. Ship in cooled container during summer months.
Remarks: Only tissue that is clearly carcinoma (established by histological criteria) should be tested. Include surgical pathology report. Submit electronic request. If you do not have electronic ordering capability, use an ARUP requisition form complete with an ARUP client number. For additional technical details, please contact ARUP Client Services at (800) 522-2787.
Unacceptable Conditions: Frozen specimens. Specimens fixed or processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives (B-4 or B-5). Depleted or no tumor in tissue. Specimens submitted with non-representative tissue type.
Stability (collection to initiation of testing): Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
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