ARUP's Laboratory Test Directory

Microsatellite Instability/HNPCC by Immunohistochemical Stain : 0049302

Mnemonic: MSI

Methodology: Immunohistochemistry
Performed: Mon, Thu
Reported: Within 5 days
Specimen Required: Collect: Paraffin-embedded, formalin-fixed tissue block enriched with colon tumor.

Storage/Transport Temperature: Paraffin-embedded, formalin-fixed tissue block enriched with colon tumor at 20-25°C. Protect paraffin block from excessive heat. Ship in cooled container during summer months. Include surgical histology report.

Remarks: Only tissue that is clearly carcinoma (established by histological criteria) should be tested.

Unacceptable Conditions: Specimens fixed/processed in alternate fixatives (alcohol, Prefer®) should not be submitted.

Stability (collection to initiation of testing): Paraffin block: Ambient: Indefinitely; Refrigerated: Acceptable; Frozen: Unacceptable
Reference Interval:
By report
Interpretive Data: Assay is performed on paraffin-embedded, formalin-fixed tissue. Antibody clone for hMLH1 is G168-15, hMSH2 is FE11, hMSH6 is 44, and hPMS2 is A16-4. The detection system is LSAB.

Background test information may be found at: www.arupconsult.com/0049302

Please refer to Statement B in the Compliance Statements section in the front of the Laboratory Test Directory.
CPT Code(s): 88342 x4
Cross References: HNPCC/Lynch Syndrome, Microsatellite Instability by Immunohistochemical Stain , Lynch Syndrome/Microsatellite Instability by Immunohistochemical Stain , MSI, Microsatellite Instability by Immunohistochemical Stain
 
 

 

 

 
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